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• Your dermatologist will calculate the amount of isotretinoin you need according to your body weight and decide on an appropriate starting dose. At future appointments the dose of Buy Generic Accutane 40 mg may be changed depending on how well you are tolerating and responding to the medication. Most patients take between 20 mg and 80 mg of isotretinoin each day, and a course commonly lasts between 16 and 24 weeks.