Dr. Jack Bert is involved in trying to avoid total knee replacement in patients with mild to moderate arthritis of the knee. Dr. Jack Bert’s research and clinical work is predicated on injection therapy using high molecular weight hyaluronic acid, stem cells or platelet rich plasma as a first step in assisting in the regeneration of normal cartilage. If this fails, then surgical intervention using cartilage transfer concepts or stem cell implantation in attempts at retarding the progression of osteoarthritis or replacing lost or worn cartilage may become necessary. Dr. Jack Bert is participating in national trials, some of which are experimental, which have shown good results in European countries and Asia.