The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Behind every great day is a great night at the Comfort Inn and Suites hotel in Sioux Falls, SD located off Interstate 29 and 229. This smoke-free hotel is located near destinations like Denny Sanford Premiere Center/Sioux Falls Arena, Sioux Falls Convention Center, Great Plains Zoo, Sioux Empire Fair and Empire Mall. Enjoy amenities like free hot breakfast, free WiFi, free weekday newspaper, guest laundry facilities and indoor heated pool and a hot tub. Rooms include HDTV, refrigerator, microwave, hair dryer, coffee maker and work desk with an ergonomic chair. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program.