The Hampton Inn Owensboro hotel is located right off the Wendell Ford Expressway in the retail area of Owensboro. Our Owensboro, Kentucky hotel is across from Towne Square Mall and just minutes from Owensboro landmarks such as the River Park Center, the Bluegrass Music Museum, Ben Hawes State Park, the Owensboro Regional Airport, three area colleges, softball complexes and more! The area immediately around our Hampton Inn offers restaurants and attractions to suit many tastes such as sporting events, a new multi-cinema complex and Broadway plays.