Welcome to the Hampton Inn & Suites – Fresno/Highway 99 CA. Hampton Inn & Suites Fresno hotel is conveniently located in the Northwest part of the city off of Highway 99 and Herndon Ave. During your stay with us, you’ll enjoy easy access to many amazing destinations in the Central Valley, such as Yosemite National Park, Sequoia National Park, Fresno Yosemite International Airport, Fresno State University, the Madera Wine Trail, and much more. Love to shop? Our Fresno, CA hotel is mere minutes from the River Park Shopping and Entertainment Center, Fashion Fair Mall, and Downtown Fresno.