The Hilton Garden Inn Sioux Falls, South Dakota hotel is located at the intersection of I-229 and Louise Avenue - only 15 minutes southwest of Sioux Falls Regional Airport and 4 blocks from The Empire Mall. The hotel is adjacent to Sioux Falls' finest restaurants and shopping, the hotel is also conveniently located near the Sioux Falls Convention Center, Sioux Falls Arena, Sanford Heath, Avera Mckennan Hospital and the Heart Hospital of South Dakota. We offer complimentary shuttle to these locations as well as Augustana College, University of Sioux Falls and Colorado Technical University.