Simplify your travel experience at Holiday Inn Express & Suites Santa Ana - Orange County.Our Santa Ana CA hotel offers modern amenities, comfortable rooms, and easy access to John Wayne Airport just seven miles away. Rest and recharge in our hotel rooms and suites with amenities like a coffee maker, free Wi-Fi, flat screen TVs, and a mini fridge. Get a great night's sleep with blackout shades in all our accommodations. Start your day with energizing selections from our complimentary breakfast buffet. Get your workout in with access to our refreshing outdoor pool and 24-hour fitness center. During your stay, visit local attractions like Santa Ana Zoo, South Coast Plaza, and Angel Stadium. We're also near corporate offices for 3M, IBM, Oracle, and more. Holiday Inn Express Santa Ana offers eight versatile meeting rooms for your upcoming meeting, wedding reception, or special occasion. Whether you're in town for business, vacation, or just passing through, enjoy a refreshing stay at Holiday Inn Express & Suites Santa Ana - Orange County. Explore our vacation packages and special offers to make the most of your stay.