Even in this time of uncertainty, Mayo Clinic is a place for hope and healing — and we're committed to delivering the care you need. With options for face-to-face, virtual visits or phone appointments in adherence with federal and state executive orders and guidance. Mayo Clinic is the best hospital overall according to U.S. News & World Report. Mayo Clinic sarcoma experts provide the best possible sarcoma care and work with you to review all of your treatment options and choose the treatment that best suits your needs and goals. The range of treatments offered to people with sarcoma includes: surgery, including innovations designed to preserve function as much as possible, such as rotationplasty and prosthetics, chemotherapy, radiation therapy, including innovative treatments such as intraoperative radiation therapy (IORT), proton therapy and clinical trials.